Coenzyme metabolic assurance of patients with recurrent
nephrolithiasis in the complex treatment by systemic enzyme therapy.
Borisov O.V. Coenzyme metabolic
assurance of patients with recurrent nephrolithiasis in the complex
treatment by systemic enzyme therapy. Urologia 1998, 3, pp. 29-35.
Odessa Medical University, Department of Urology, Odessa, Ukraine
In addition to clinico-immunological investigation, the metabolic
supply of enzymatic systems with pyridoxal phosphate and thiamin
pyrophosphate was studied in 50 patients with recurrent
nephrolithiasis complicated by chronic pyelonephritis. It was
established that the value of thiamin pyrophosphate - effect was
reliably increased in patients with nephrolithiasis, this witnessing
the insufficient metabolic supply with coenzyme form of vitamin
B1-cocarboxylase. There was a strong tendency to the growth of
pyridoxal phosphate-effect. The complex treatment of patients
included antiinflammatory, antibacterial therapy, as well as
operative intervention in the upper urinary tract. 25 patients
additionally received polyenzyme preparation Phlogenzym in the early
postoperative period (for 2-3 weeks) and as out-patients (for 2
weeks more). The complex treatment of nephrolithic patients with the
use of Phlogenzym produced marked normalizing influence on the value
of pyridoxal phosphate-effect which is indicative of the reduction
of alterations in the urinary tract tissues. The postoperative
period had a favourable course, and the control check-up carried out
12 months later revealed that the incidence of lithogeny recurrence
was reliably lower than in the control group.